Image of human RPA complex bound to ssDNA

Model of the human RPA complex bound to ssDNA.

All domains of RPA are shown with RPA1 in green, RPA2 in blue, RPA3 in red and ssDNA in black.  Model was developed using the known structures of the domains of RPA and the structure of Ustalago RPA bound to DNA (Fan J & Pavletich NP. 2012. Genes Dev 26:2337).  For more details about RPA-DNA interactions see Chen, R. and Wold, M.S. (2014) “Replication protein A: Single-stranded DNA's first responder: Dynamic DNA-interactions allow replication protein A to direct single-strand DNA intermediates into different pathways for synthesis or repair”Bioessays doi: 10.1002/bies.201400107.  PMID:25171654.

Chen and Wold -Bioessays

Events

Biochemistry and Molecular Biology Seminar: Dr. Rui Zhao promotional image

Biochemistry and Molecular Biology Seminar: Dr. Rui Zhao

Thursday, February 26, 2026 10:30am to 11:20am
Medical Education Research Facility

This event is open to the public.

Mechanisms and Modulation of 5' Splice Site Recognition

Rui Zhao, PhD
University of Colorado Anschutz

Faculty Host: Lori Wallrath, PhD

College of Pharmacy PSET Seminar Series: Kristina Thiel, PhD promotional image

College of Pharmacy PSET Seminar Series: Kristina Thiel, PhD

Tuesday, March 3, 2026 11:30am
College of Pharmacy Building

The Department of Pharmaceutical Sciences and Experimental Therapeutics (PSET) in the College of Pharmacy will host a seminar presented by: 

Kristina Thiel, PhD
Assistant Professor
Department of Obstetrics and Gynecology
University of Iowa
Iowa City, Iowa

All are welcome to attend. No pre-registration required.

BMB Research Workshop promotional image

BMB Research Workshop

Tuesday, March 3, 2026 12:30pm to 1:20pm
Medical Education Research Facility

The Department of Biochemistry and Molecular Biology holds research workshops featuring internal speakers on Tuesdays, 12:30-1:20pm. For Spring 2026, these will occur in 2117 MERF. Presentation titles are not publicly available due to the use of unpublished research. Individuals interested in attending workshops or being added to the email list should contact the office at biochem@uiowa.edu.

Jan. 20: CANCELED

Jan. 27: Lori Wallrath, PhD, Professor of Biochemistry and Molecular Biology

Feb. 3...