Image of human RPA complex bound to ssDNA

Model of the human RPA complex bound to ssDNA.

All domains of RPA are shown with RPA1 in green, RPA2 in blue, RPA3 in red and ssDNA in black.  Model was developed using the known structures of the domains of RPA and the structure of Ustalago RPA bound to DNA (Fan J & Pavletich NP. 2012. Genes Dev 26:2337).  For more details about RPA-DNA interactions see Chen, R. and Wold, M.S. (2014) “Replication protein A: Single-stranded DNA's first responder: Dynamic DNA-interactions allow replication protein A to direct single-strand DNA intermediates into different pathways for synthesis or repair”Bioessays doi: 10.1002/bies.201400107.  PMID:25171654.

Chen and Wold -Bioessays

Events

Mini-Symposium on Nuclear Structure and Function: Chromosomes, Chromatin Protein and the Nuclear Lamina

Thursday, November 21, 2024 10:30am to 5:30pm
Medical Education Research Facility
Featuring speakers: "Pairing: from Pam to super-resolution" Ting Wu, PhD, Harvard Medical School "How common is meiotic drive?" Daniel Barbash, PhD, Cornell University "Nuclear lamins and their partners in mitosis, tissue-specific disease, addiction, and beyond" Katherine Wilson, PhD, Johns Hopkins University "The role of the nuclear envelope and NEMP in metazoan fertility and mechanotransduction" Helen McNeill, PhD, Washington University in St. Louis This event is free and open...

Biochemistry and Molecular Biology Research Workshop

Tuesday, December 3, 2024 12:30pm to 1:20pm
Medical Education Research Facility
This workshop has been canceled. 
Canceled

Biochemistry and Molecular Biology Research Seminar

Thursday, December 5, 2024 10:30am to 11:20am
Medical Education Research Facility
Please contact the department at biochem@uiowa.edu for more information for more information about this event.