Image of human RPA complex bound to ssDNA

Model of the human RPA complex bound to ssDNA.

All domains of RPA are shown with RPA1 in green, RPA2 in blue, RPA3 in red and ssDNA in black.  Model was developed using the known structures of the domains of RPA and the structure of Ustalago RPA bound to DNA (Fan J & Pavletich NP. 2012. Genes Dev 26:2337).  For more details about RPA-DNA interactions see Chen, R. and Wold, M.S. (2014) “Replication protein A: Single-stranded DNA's first responder: Dynamic DNA-interactions allow replication protein A to direct single-strand DNA intermediates into different pathways for synthesis or repair”Bioessays doi: 10.1002/bies.201400107.  PMID:25171654.

Chen and Wold -Bioessays

Events

Biochemistry and Molecular Biology Seminar: Dr. Brad Webb promotional image

Biochemistry and Molecular Biology Seminar: Dr. Brad Webb

Thursday, October 9, 2025 10:30am to 11:20am
Medical Education Research Facility

This event is open to the public.

"Cell Biology of Metabolism: Structural and Functional Insights into a Glycolytic Enzyme"

Bradley Webb, PhD
West Virginia University Health Sciences Center

Faculty Host: Anthony Pedley, PhD

Webb Lab | https://medicine.hsc.wvu.edu/biochemistry/research-labs/bradley-webb/

Scientific Careers Symposium promotional image

Scientific Careers Symposium

Friday, October 10, 2025 12:00pm to 4:30pm
Medical Education Research Facility
An excellent opportunity to explore diverse career paths in the biomedical sciences.

Biochemistry and Molecular Biology Seminar: Dr. Shelley Minteer

Thursday, October 23, 2025 10:30am to 11:20am
Medical Education Research Facility

This event is open to the public.

"TBA"

Shelley Minteer, PhD
Missouri University of Science and Technology

Faculty Host: Anthony Pedley, PhD

Minteer Lab | https://sites.mst.edu/shelleyminteer/research/