Image of human RPA complex bound to ssDNA

Model of the human RPA complex bound to ssDNA.

All domains of RPA are shown with RPA1 in green, RPA2 in blue, RPA3 in red and ssDNA in black.  Model was developed using the known structures of the domains of RPA and the structure of Ustalago RPA bound to DNA (Fan J & Pavletich NP. 2012. Genes Dev 26:2337).  For more details about RPA-DNA interactions see Chen, R. and Wold, M.S. (2014) “Replication protein A: Single-stranded DNA's first responder: Dynamic DNA-interactions allow replication protein A to direct single-strand DNA intermediates into different pathways for synthesis or repair”Bioessays doi: 10.1002/bies.201400107.  PMID:25171654.

Chen and Wold -Bioessays

Events

Biochemistry and Molecular Biology Research Workshop: Adrian Elcock, DPhil

Tuesday, October 15, 2024 12:30pm to 1:20pm
Medical Education Research Facility
Presentation by:  Adrian Elcock, DPhil Professor of Biochemistry and Molecular Biology Please note: Workshop presentation titles are not provided publicly in order to protect intellectual property.  Please contact biochem@uiowa.edu if you would like more information.  

Biochemistry and Molecular Biology Seminar: Dr. Aaron Hobbs

Thursday, October 17, 2024 10:30am to 11:20am
Medical Education Research Facility
This event is open to the public.  "Not all KRAS mutants are created equal: how atypical KRAS mutants differentially drive pancreatic cancer" Aaron Hobbs, PhD Assistant Professor Department of Cell and Molecular Pharmacology and Experimental Therapeutics Medical University of South Carolina Aaron Hobbs | Musc Hobbs Lab (hobbslabmusc.com)

Biochemistry and Molecular Biology Research Workshop: Lucy Langmack 4th Year Workshop

Tuesday, October 22, 2024 12:30pm to 1:20pm
Medical Education Research Facility
Presentation by: Lucy Langmack PhD Candidate Biochemistry and Molecular Biology Advisor: Ted Abel, PhD Please note: Workshop presentation titles are not provided publicly in order to protect intellectual property. Please contact biochem@uiowa.edu if you would like more information.