Image of human RPA complex bound to ssDNA

Model of the human RPA complex bound to ssDNA.

All domains of RPA are shown with RPA1 in green, RPA2 in blue, RPA3 in red and ssDNA in black.  Model was developed using the known structures of the domains of RPA and the structure of Ustalago RPA bound to DNA (Fan J & Pavletich NP. 2012. Genes Dev 26:2337).  For more details about RPA-DNA interactions see Chen, R. and Wold, M.S. (2014) “Replication protein A: Single-stranded DNA's first responder: Dynamic DNA-interactions allow replication protein A to direct single-strand DNA intermediates into different pathways for synthesis or repair”Bioessays doi: 10.1002/bies.201400107.  PMID:25171654.

Chen and Wold -Bioessays

Events

Biochemistry and Molecular Biology Seminar: Dr. Scott Williams (NIEHS/NIH)

Thursday, November 7, 2024 10:30am to 11:20am
Medical Education Research Facility
This event is open to the public. "Structure and Function of Sf1b Helicases Regulating Cellular Transcription and Viral Replication" R. Scott Williams, PhD Acting Chief, Genome Integrity and Structural Biology Laboratory National Institute of Environmental Health Sciences National Institutes of Health Faculty host: Dr. Maria Spies

Biochemistry and Molecular Biology Research Workshop: Sarah Jordan 5th Semester Seminar

Tuesday, November 12, 2024 12:30pm to 1:20pm
Medical Education Research Facility
Presentation by:  Sarah Jordan PhD Candidate Biochemistry and Molecular Biology Advisor: Todd Washington, PhD Please note: Workshop presentation titles are not provided publicly in order to protect intellectual property.  Please contact biochem@uiowa.edu if you would like more information.

Biochemistry and Molecular Biology Seminar: Dr. Judith Simcox

Thursday, November 14, 2024 10:30am to 11:20am
Medical Education Research Facility
This event is open to the public. Title TBD Judith Simcox, PhD HHMI Freeman Hrabowski Scholar Assistant Professor Department of Biochemistry University of Wisconsin-Madison Simcox, Judith – Department of Biochemistry – UW–Madison (wisc.edu)