Image of human RPA complex bound to ssDNA

Model of the human RPA complex bound to ssDNA.

All domains of RPA are shown with RPA1 in green, RPA2 in blue, RPA3 in red and ssDNA in black.  Model was developed using the known structures of the domains of RPA and the structure of Ustalago RPA bound to DNA (Fan J & Pavletich NP. 2012. Genes Dev 26:2337).  For more details about RPA-DNA interactions see Chen, R. and Wold, M.S. (2014) “Replication protein A: Single-stranded DNA's first responder: Dynamic DNA-interactions allow replication protein A to direct single-strand DNA intermediates into different pathways for synthesis or repair”Bioessays doi: 10.1002/bies.201400107.  PMID:25171654.

Chen and Wold -Bioessays

Events

Biochemistry Seminar: "Dynamic Assembly of RNA Processing Machines" promotional image

Biochemistry Seminar: "Dynamic Assembly of RNA Processing Machines"

Thursday, October 15, 2026 10:30am to 11:20am
Medical Education Research Facility

"Dynamic Assembly of RNA Processing Machines"

Presented by

Aaron Hoskins, Ph.D.
Wasson Professor in Biochemistry
University of Wisconsin-Madison

BMB Research Workshop

Tuesday, October 20, 2026 12:30pm to 1:20pm
Medical Education Research Facility

The Department of Biochemistry and Molecular Biology holds research workshops featuring internal speakers on Tuesdays, 12:30-1:20pm. For Fall 2026, these will occur in 1117 MERF. Presentation titles are not publicly available due to the use of unpublished research. Individuals interested in attending workshops or being added to the email list should contact the office at biochem@uiowa.edu.

Aug. 25: CANCELED

Sept. 1: CANCELED

Sept. 8: RESERVED

Sept. 15: Steve Guzman, PhD, Postdoc Fellow, Biomedical...

Joseph Walder Memorial Lecture with Dr. Taekjip Ha, Harvard Medical School promotional image

Joseph Walder Memorial Lecture with Dr. Taekjip Ha, Harvard Medical School

Thursday, October 22, 2026 10:30am to 11:20am
Medical Education Research Facility

Dr. Ha will be our speaker for the inaugural Joseph Walder Memorial Lecture.

"Genome Maintenance at Higher Resolution"

Taekjip Ha, Ph.D.
George D. Yancopoulos Professor of Pediatrics in honor of Frederick W. Alt
Harvard Medical School
Boston Children’s Hospital
Investigator, Howard Hughes Medical Institute